Chromatin biochemistry enters the next generation of code 'seq-ing'

Multicarrier code for the next-generation GPS

This article investigates multicarrier (MC) transmission for next-generation global positioning system (GPS) instead of current spread spectrum signals. A MC code is proposed in this article as an alternative to the coarse/acquisition (C/A) code in GPS. The entire GPS bandwidth for the C/A code is divided into 1,024 subcarrier slots. As per our proposed arrangement, each satellite vehicle (SV) ...

The Biochemistry of Chromatin Remodeling.

Next generation microfluidic platforms for high-throughput protein biochemistry.

DNA technologies such as cloning, DNA microarrays, and next generation sequencing have transformed the life sciences. Protein technologies on the other hand have not seen such explosive progress. This is mainly due to the inherent difficulty of working with proteins because of their manifold physical characteristics as opposed to the well behaved and well understood DNA polymer. Recent technolo...

Uncovering RNAi mechanisms in plants: biochemistry enters the foray.

In plants, the RNA interference (RNAi) machinery responds to a variety of triggers including viral infection, transgenes, repeated elements and transposons. All of these triggers lead to silencing outcomes ranging from mRNA degradation to translational repression to chromatin remodeling. Thus, plants offer us a potentially unique opportunity to understand the full range of RNAi effector mechani...

“Seq-ing” Insights into the Epigenetics of Neuronal Gene Regulation

The epigenetic control of neuronal gene expression patterns has emerged as an underlying regulatory mechanism for neuronal function, identity, and plasticity, in which short- to long-lasting adaptation is required to dynamically respond and process external stimuli. To achieve a comprehensive understanding of the physiology and pathology of the brain, it becomes essential to understand the mech...